Scientist, Cell Therapy Bioscience Job at AstraZeneca, Gaithersburg, MD

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  • AstraZeneca
  • Gaithersburg, MD

Job Description

AstraZeneca seeks a scientist to conduct in vitro discovery work on engineered cell therapies, particularly CAR-T platforms. The role combines hands-on laboratory experimentation with platform development, requiring expertise in immune-cell biology, functional assays, and flow cytometry to advance translational cell therapy programs.

Responsibilities

  • Independently conduct, troubleshoot and analyze in vitro cell therapy and immunology experiments
  • Culture, characterize, and phenotype primary T and NK cells; engineer cells using viral or non-viral approaches
  • Design and execute multiparameter flow cytometry experiments including panel design, staining, acquisition and analysis
  • Develop, optimize and apply reusable assays, workflows and data-analysis approaches for cell therapy platform capabilities
  • Collaborate across multidisciplinary teams to integrate functional assay, flow cytometry and omics data; maintain accurate records and communicate findings through reports and presentations

Requirements

  • BS or MS in Immunology, Cell Biology, Molecular Biology, Bioengineering, or related discipline
  • 3+ years of relevant research experience in cell therapy, immunology, or immuno-oncology
  • Hands-on experience culturing primary human immune cells and established tumor cell lines
  • Proficiency in flow cytometry acquisition, analysis, and interpretation
  • Experience designing and executing immune-cell functional assays (cytotoxicity, proliferation, activation, cytokine measurement)
  • Practical knowledge of T-cell and/or NK-cell biology and cellular engineering
  • Strong experimental design, troubleshooting, documentation and communication abilities

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